Description
SOBIMED tablet is Sodium Bicarbonate tablet which is used as an alkalinizing agent in the treatment of metabolic acidosis. Sodium bicarbonate also may be used as an alkalinizing agent in advanced cardiovascular life support (ACLS) during cardiopulmonary resuscitation (CPR) and in the treatment of certain intoxications to decrease renal reabsorption of the drug or to correct acidosis.

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Sodium Bicarbonate also is used to increase urinary pH in order to increase the solubility of certain weak acids or in the treatment of hemolytic reactions requiring alkalization of the urine to diminish the nephrotoxic effects of blood pigments. In addition, the drug is used in the treatment of severe diarrhea accompanied by substantial GI bicarbonate loss and as an adjunct in the treatment of hyperkalemia to induce the cellular uptake of potassium and return the ratio of intracellular to extra cellular potassium concentration toward normal. Composition:
Each film-coated tablet of SOBIMED500tablet contains film coated Sodium Bicarbonate I.P. 500 mg.

Indications:
SOBIMED tablet is indicated in the treatment of metabolic acidosis; promotion of gastric, systemic, and urinary alkalinization; replacement therapy in severe diarrhea; used to reduce incidence of chemical phlebitis.

Dosage & administration:

• The dose of Sodium Bicarbonate will be different for different patients.

Storage:
Store in a cool, dry place. Protect from light and moisture.

Presentation:
SOBIMED500is available as tablets in a blister of 10 tablets and 10 such blisters in a box.

Description
NUMOLOG TABLET contains all amino acids essential for uremic patients, five out of them are keto or hydroxyanalogue in the form of calcium salts. Therefore it allows reduction in the nitrogen supply and provides calcium. It is a medication for the treatment of chronic kidney disease patients on Conservative management therapy (CKD stage I, II, III). In combination with very low protein diet / low protein diet, it helps in delaying the progression of kidney disease in the Predialysis period. .

Indications:
Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of 40 g per day (for adults) and less; i.e. generally in patients with a glomerular filtration rate (GFR) below 25 ml/min.

Dosage and Administration:
In general, unless prescribed otherwise, four to eight tablets are swallowed whole three times daily during meals. This dosage applies to adults (70 kg bodyweight) (1 tablet/5 kg body weight/day).

Storage:

• Keep out of the reach of children
• Do not store above 25°C
• Protect from moisture

Presentation:
NUMOLOG is available as tablets in a Alu of 10 tablets and 10 such Alu in a box

Description
1) Improvement of metabolic complications due to renal insufficiency (e.g. proteinuria, disturbances in calcium-phosphate, carbohydrate and lipid metabolism)
2) Preservation of the residual renal function and therefore slowing down the rate of progression of the chronic kidney disease and delaying the onset of dialysis .

3) Reduction of uremic symptoms, which are largely due to an accumulation of degradation products of the protein metabolism 4) Preservation of the nutritional status, despite the marked reduction of the daily protein intake

Indications:
Prevention & therapy of damages due to CKD till GFR is 15 ml/min, i.e. stages II, III & IV of CKD

Dosage :
1 Tablet/10 kg body weight/day along with meal, divided in 3 equal dosage

Description
TOXOPRO 15 is a Pre-Probiotic combination, a blend of probiotic Lactobacillus and Bifidobacterium species, the two most important genuses associated with the human intestinal tract and oral adsorbent Lactitol monohydrate.
Patients with chronic disease have abnormal microbiota when compared to healthy individuals. Diet and impaired protein absorption, increased intestinal transit time, medications, and uremia may all contribute to unfavorable changes in microbiota. Probiotic is used to maintain a friendly bacterial balance for support to healthy digestion. Probiotics are used to eliminate uremic toxics in CKD patients and in patients undergoing dialysis. .

Composition:

Bifidobacterium longum	5 Billion CFU
Lactobacillus acidophilus	5 Billion CFU
Streptococcus Thermophilus	5 Billion CFU
Total Count	15 Billion CFU
Fructo-Oligosaccharides	100 mg

Indication:
TOXOPRO 15 is indicated in Renal Impairment for reducing the burden on impaired kidney.

Dosage & administration:

• The recommended dosage of TOXOPRO 15 in CKD is 1-2 capsules with every meal. The dose should be adjusted to suit the requirements of the individual patients.

Presentation:
TOXOPRO 15 is available as hard gelatin capsules in a Alu-Alu pack of 10 capsules and 10 such Alu-Alu in a box.

Description
Toxopro-Forte is a synbiotic combination of Pre & Probiotics: Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacteriumlongum and Fructooligosaccharide. Toxopro-Forte is believed to prevent kidney stone formation by breaking down or degrading calcium oxalate in the intestinal tract before it can move into the kidneys. Toxopro-Forte decreases Uremia, Blood Nitrogen levels, and Ammonia Levels. .

Key Benefits

• Toxopro-Forte (Probiotics) are live micro-organisms that confer good health to human beings when consumed in adequate quantities and also prevent the colonisation of pathogenic bacteria.
• Fructooligosaccharide in Toxopro-Forte acts as a prebiotic and helps in the removal of proteinaceous by-products that lead to renal failure
• Toxopro-Forte is a Complete, Convenient & Compliant approach to reducing the Uremic load on kidneys.

Directions For Use
The dose and duration of Toxopro-Forte should be followed as advised by the healthcare professional.

Safety Information

• Keep it away from the reach of children.
• Store in a cool and dry place

Presentation
Toxopro-Forte is available as Capsules in aAlu of 10 Capsule and 3 such Alu in a box

Description
SEVMED contains sevelamer carbonate, a non-absorbed phosphate binding crosslinked polymer, free of metal and calcium. It contains multiple amines separated by one carbon from the polymer backbone. These amines exist in a protonated form in the intestine and interact with phosphate molecules through ionic and hydrogen bonding. By binding phosphate in the gastrointestinal tract and decreasing absorption, Sevelamer carbonate lowers the phosphate concentration in the serum (serum phosphorus). .

Indication & usage:
Sevmed (Sevelamer Carbonate 400/800 mg) is a phosphate binder indicated in Hyperphosphatemia for the control of serum phosphorus in patients with Chronic Kidney Disease on dialysis.

Dosage & administration:

• Patient must take Sevmed three times a day with meals.
• Sevmed dose is concluded depending upon the serum phosphorus levels in the body.

Presentation:
Sevmed 400 & Sevmed 800 is available as white colour,10 such tablets are packed in a Alu strip and 10 such strips in a carton.

Description
SPECIUM (Calcium acetate) is used to control phosphate levels to keep them getting too high in people with kidney failure. In hyperphosphatemia, SPECIUM binds with the phosphate in the blood and eliminates it as urine or stool. .

Composition
Each Film Coated tablet of SPECIUM ™ contains 667 mg Calcium Acetate.

Indication
SPECIUM Tablet is a phosphate binder indicated to reduce serum phosphorus in patients with end stage renal disease (ESRD).

Mechanism of action
SPECIUM when taken with meals, combines with dietary phosphate to form an insoluble calcium phosphate complex, which is excreted in the feces, resulting in decreased serum phosphorus concentration.

Dosage

• The recommended initial dose of SPECIUM Tablets for the adult dialysis patient is 2 Tablets with each meal.
• Most patients require 3-4 capsules with each meal.
• SPECIUM dose is concluded depending upon the serum phosphorus levels in the body.

Presentation
SPECIUM is available as a strip of 10 tablets in Blister Packing.

Description
FAFUNIC (Febuxostat) is used to lower hyperuricemia (high uric acid in the blood) in patients with gout who have been treated with allopurinol that did not work well or cannot be treated with allopurinol. This medicine is a xanthine oxidase inhibitor. It works by causing less uric acid to be produced by the body. .

Composition
Each Tablet Of FAFUNIC -40 Contains 40 Mg Of Febuxostat.

Indication
FAFUNIC 40 Is Used Indicated for the chronic management of hyperuricemia in patients having over production of Uric acid.

Mechanism of action
FAFUNIC (febuxostat) evaluated in trials was the inhibition of xanthine oxidase, evidenced by the increase in serum and urine xanthine concentrations, decrease in serum and urine uric acid levels, and lack of significant reduction in total purine synthesis. In the purine metabolism cascade, xanthine oxidase converts hypoxanthine to xanthine and xanthine to uric acid.

Dosage
The recommended starting dose of FAFUNIC 40 is 40 mg once daily without regard to food or antacid use.

Presentation
FAFUNIC 40 is available as a strip of 10 tablets.

Description
RETAUNCH is a combination of N-Acetylcysteine and Taurine that acts synergistically to attenuate glomerular damage and microalbuminaria in diabetic kidney disease patients. N- Acetylcysteine. .

N-Acetylcysteine (also known as N-acetyl-L-cysteine or NAC) is a derivative of cysteine with an acetyl group attached to the amino group of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores. Taurine
Taurine is a type of conditionally essential amino acid found throughout the body. It is particularly concentrated in the brain, eyes, heart and muscles. It comprises of over 50% of the total free amino acid pool of the heart. Taurine plays role in several biological processes in the kidney and helps in improving renal blood flow and endothelial cell function. Taurine has been shown to play a role in four different forms of kidney disease: glomerulonephritis, diabetic nephropathy, chronic renal failure, and acute kidney injury Studies have shown that glomerular damage in diabetes can be prevented or at least attenuated by supplementation with Taurine and N-Acetylcysteine. Also Taurine in combination with N-Acetylcysteine was useful in attenuating urinary albumin to creatinine ratio and sTGF-β1 levels in microalbuminuric type 2 diabetic patients. The benefits of taurine therapy on kidney function and blood pressure are noteworthy and may be useful in preventing the deterioration of microalbuminuria in diabetic kidney disease patients.

Composition
Each tablet of RETAUNCH contains N-Acetylcysteine 150mg and Taurine 500mg.